Physical Frailty

Supporting the growth of new muscle

Most of us, as we get older, want to maintain a healthy body and mind. In addition to exercise and a balanced diet, people are looking for ways to enhance their ability to stay active. Sarcopenia is a geriatric syndrome defined as the loss of muscle mass, strength and function. It has a high clinical impact as well as affecting a patient’s quality of life due to a decline in mobility and independence. We have carried out in-depth research into muscle loss and the process of protein formation, which is proving to be important in the area of muscle health and mobility.

Our muscles renew, or regenerate, at a rate of 2% per day.

Over the course of three months, all the muscles in our arms are renewed. To stay fit, it is important that the body retains the ability to create new muscle to replace the old. Dietary proteins are known to support the growth of muscle cells. Our research therefore concentrates on how advanced nutrition can have a positive effect on the rate at which new muscle cells are created.

 

References:

  1. Anthony JC, et al. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr. 2000;130(10):2413-9.
  2. Bauer JM, et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc. 2015;16(9):740-7.
  3. Boirie Y, et al. Fast digestive proteins and sarcopenia of aging. Curr Opin Clin Nutr Metab Care. 2018;21(1):37-41.
  4. Boirie Y, et al. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA. 1997;94(26):14930-14935.
  5. Boirie Y. Fighting sarcopenia in older frail subjects: protein fuel for strength, exercise for mass. J Am Med Dir Assoc. 2013;14(2):140-3.
  6. Chanet A, et al. Vitamin D supplementation restores the blunted muscle protein synthesis response in deficient old rats through an impact on ectopic fat deposition. J Nutr Biochem. 2017;46:30-8.
  7. Churchward-Venne TA, et al. Alterations in human muscle protein metabolism with aging: Protein and exercise as countermeasures to offset sarcopenia. Biofactors. 2014;40(2):199-205.
  8. Cruz-Jentoft AJ, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-3.
  9. Cuthbertson D, et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. 2005;19(3):422-4.
  10. Dangin M, et al. The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am J Physiol Endocrnol Metab. 2001;280(2):E340-E348.
  11. Domingues-Faria C, et al. Vitamin D and muscle trophicity. Curr Opin Clin Nutr Metab Care. 2017;20(3):169-174.
  12. Katsanos CS, et al. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006;291(2):E381-E387.
  13. Kim TN, et al. Sarcopenia: Definition, Epidemiology, and Pathophysiology. J Bone Metab. 2013;20(1):1-10.
  14. Koopman R, et al. Aging, exercise, and muscle protein metabolism. J Appl Physiol. 2009;106(6):2040-8.
  15. Luiking YC, et al. Protein type and caloric density of protein supplements modulate postprandial amino acid profile through changes in gastrointestinal behaviour: A randomized trial. Clin Nutr. 2016;35(1):48-58.
  16. Pennings B, et al. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr. 2011;93(5):997-1005.
  17. Phillips SM, et al. Alterations of protein turnover underlying disuse atrophy in human skeletal muscle. J Appl Physiol. 2009;107(3):645-54.
  18. Puthucheary ZA, et al. Acute Skeletal Muscle Wasting in Critical Illness. JAMA. 2013;310(15):1591-1600.
  19. Salles J, et al. 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. Mol Nutr Food Res. 2013;57(12):2137-46.
  20. Van Wijngaarden JP, et al. Leucine- Enriched whey Protein Medical Nutrition Drinks in Powder and Liquid Format Result in Higher Postprandial Serum Amino Acid Levels Compared to Standard Casein-Dominant Medical Nutrition Drinks. Clin Nutr. 2017;36:S158-S9.
  21. Volpi E, et al. The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly. J Clin Endocrinol Metab. 2000;85(12):4481-4490.